This is a summary of the natural history of MASH, which reviews the key characteristics and epidemiology of different disease stages.
This image of a healthcare professional was generated using artificial intelligence.
A dedicated hub providing key information on metabolic dysfunction-associated steatohepatitis (MASH), useful educational resources to support clinical practice, and news about upcoming events.
Image of fibrotic liver from MASH progression leavepiece.
MASH is a rapidly growing public health concern in the UK, with a prevalence of approximately 5%.1
It is often clinically silent allowing undetected disease progression.2,3
Worsening fibrosis increases the risk of complications and mortality, emphasising the need for timely intervention.4-6
Event details and useful resources from key congresses in the MASH community.
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These resources aim to improve understanding of MASH and support clinical practice.
This is a summary of the natural history of MASH, which reviews the key characteristics and epidemiology of different disease stages.
This is a guidelines-based algorithm for the non-invasive risk stratification of patients with metabolic dysfunction-associated steatotic liver disease (MASLD), and a summary of risk-related thresholds for relevant investigations.
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Reference ID
Citation
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Younossi ZM et al. Clin Gastroenterol Hepatol. 2025;S1542–3565(25)00757–8.
Luthra R, Sheth A. Adv Ther. 2025;42:1165–95.
Povsic M et al. Adv Ther. 2019;36(7):1574–94.
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Nabi O et al. Dig Dis Sci. 2022;67(6):2584–93.
Taylor RS et al. Gastroenterology. 2020;158:1611–25.e12.
EASL, EASD, EASO. J Hepatol 2024;81:492–542.
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